I haven't noticed the following in 18.1 but it used to be there in earlier versions:
You have to have the relevant layer visible both in the viewport, and also in the drawing in model space, IF you have changed anything since you opened the drawing. In other words, the viewport works fine when you open up the drawing, but if you change anything, sometimes the viewport layer visibility gets controlled by the main layer visibility, rather than being independent of it. No doubt sometimes it does this even if you don't change anything, but I haven't noticed that.
So I'd suggest you turn on the layer that the viewport is supposed to show both in the viewport itself, and in the Design Director. Print it, and then turn that layer back off if you need to.
Windows 7 ultimate, Core i7 3.07GHz, 4 cores, 9G memory GEForce GTX 285