I don't know if you had the lightworks plug-in for 2017, but if not, 2018 uses GDI mode (options menu - native draw) and lightworks rendering, which is completely different to RedSDK.
As far as OpenGL, when I work with DGI mode I make sure OpenGL hardware acceleration is turned off, (options menu - Desktop), because it does not play well with my old system. you could try it both on and off to see whether it causes any problems with your system. basically ( as far as I know), if turned on it will have a look at your graphics card drivers and see if some rendering can be done on the card, but trying to render 2D stuff (foreground wireframe option) may not work properly.
As for the mouse button, There is a section in tools menu - customise, Devises, additional device setup button. But on my mouse, if I single click my extra button it zooms extents, but if I click and hold it down, whilst moving the mouse it rotates the view, is this the type of thing you mean. I did have to tell my mouse properties in windows, to operate the button as a wheel click.
Sorry. Cannot comment on any hanging as I don't have 2018 Deluxe. (you could try turning off, OpenGL acceleration if it is turned on). also right click the rendering teacup, and check if draft is set to Lightworks or OpenGL.