After getting Windows 10 64 Bit running, I found that I couldn't use my 15+ year old scanner to work. It couldn't be found but I kept trying to install it over and over again and using several versions of the software until I had the scanner show up in Device Manager and "working properly" even though the program itself wouldn't work yet. It was an issue of 32 Bit programs. However, an old printer worked without hesitation so I kept on trying and restarting the computer dozens of times.
I found a video on YouTube that fixed it for me: https://www.youtube.com/watch?v=Kyoyorh-YGQ
I have my scanner working. From Control Panel I went to Programs and Features and turned Windows features ON. I then found "Internet Information Services" and in Advanced I made "Enable 32 bit Applications" TRUE. Then restarted the computer. I checked for compatibility with "Troubleshoot Compatibility" and ran as administrator and the program suddenly appeared.
Anytime there are problems with Windows 10 do a search on the web for solutions. I hope this helps if anyone is having problems.