That depends what you mean by "clean up". TC edits meshes well, but it doesn't make them CAD objects or give them physics, so it doesn't fillet edges or shell them without converting them to solids. Conversion to solids is a major choke point and probably limited to objects with fewer than, say, 20K facets, probably less in practical terms, and once that's done, the object isn't editable like a mesh would be. If meshes have got lots of triangles, things slow down a lot, but TC does proper mesh booleans pretty well, so volume meshes add, subtract and intersect their volumes, and you can slice them up and edit portions independently to speed things up and then combine the parts again, and it's possible to create offsets to give meshes shell thickness. But TC doesn't sculpt mesh surfaces like Meshmixer or Dilay, it's utilitarian editing, not freeform creative process, and if you've performed mesh editing on your .stl object, your new object probably doesn't conform to the .stl format anymore, because that has pretty strict rules about how many facets can share edges and vertices. Meshmixer and Netfabb can repair things, but I've heard people blame TC for not producing a true .stl after they've imported one and hacked it about.
If you mean that your object is 130K facets, I think that that's going to be a big ask of any app, and I don't think any retail CAD app is good for that. There are apps that convert meshes into nurb objects, but many require the meshes to be "retopologised", converted from triangle-dominated to quadrilateral-dominated for nurb conversion to work.