There is no definitive answer, IMHO.
It depends so much on your needs, ability and bank balance.
For instance, Designer is a brilliant, cost-effective 2-D program, which may satisfy many purchasers.
Platinum Pro has all the bells and whistles, but comes with higher learning and financial costs.
Every version, whether 64-bit or not, can have issues for some, but not others.
It's a bit like answering "how long is a piece of string?"
Just my two cents.